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Index > Protein center > FAAH(Gene name) > Human
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  • FAAH (Gene name),
  • Fatty-acid amide hydrolase 1 (Protein name ),  FAAH1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    FAAH(FAAH1);
    Protein name:
    Fatty-acid amide hydrolase 1;
    Alternative:
    Oleamide hydrolase 1;Anandamide amidohydrolase 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.
    Subcellular Location:
    Endomembrane system Single-pass membrane protein Cytoplasm cytoskeleton Seems to be attached to intracellular membranes and a portion of the cytoskeletal network.
    Protein Attributes:
    Sequence length:
    579
    Sequence:
    50:
    MVQYELWAAL | PGASGVALAC | CFVAAAVALR | WSGRRTARGA | VVRARQRQRA | 
    100:
    GLENMDRAAQ | RFRLQNPDLD | SEALLALPLP | QLVQKLHSRE | LAPEAVLFTY | 
    150:
    VGKAWEVNKG | TNCVTSYLAD | CETQLSQAPR | QGLLYGVPVS | LKECFTYKGQ | 
    200:
    DSTLGLSLNE | GVPAECDSVV | VHVLKLQGAV | PFVHTNVPQS | MFSYDCSNPL | 
    250:
    FGQTVNPWKS | SKSPGGSSGG | EGALIGSGGS | PLGLGTDIGG | SIRFPSSFCG | 
    300:
    ICGLKPTGNR | LSKSGLKGCV | YGQEAVRLSV | GPMARDVESL | ALCLRALLCE | 
    350:
    DMFRLDPTVP | PLPFREEVYT | SSQPLRVGYY | ETDNYTMPSP | AMRRAVLETK | 
    400:
    QSLEAAGHTL | VPFLPSNIPH | ALETLSTGGL | FSDGGHTFLQ | NFKGDFVDPC | 
    450:
    LGDLVSILKL | PQWLKGLLAF | LVKPLLPRLS | AFLSNMKSRS | AGKLWELQHE | 
    500:
    IEVYRKTVIA | QWRALDLDVV | LTPMLAPALD | LNAPGRATGA | VSYTMLYNCL | 
    550:
    DFPAGVVPVT | TVTAEDEAQM | EHYRGYFGDI | WDKMLQKGMK | KSVGLPVAVQ | 
    579:
    CVALPWQEEL | CLRFMREVER | LMTPEKQSS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    MIM:
    SMR:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Fatty-acid amide hydrolase 1
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    E15331m
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    ELISA Kit for Human Fatty-acid amide hydrolase 1
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    ELISA Kit for Human Fatty-acid amide hydrolase 1
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    ELISA Kit for Human Fatty-acid amide hydrolase 1
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    CLIA Kit for Human Fatty-acid amide hydrolase 1
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    U15331m
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    Packing:
    96T
    CLIA Kit for Human Fatty-acid amide hydrolase 1
    Cat.:
    U15331r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Fatty-acid amide hydrolase 1
    Cat.:
    U15331h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Fatty-acid amide hydrolase 1
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    U15331p
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Fatty-acid amide hydrolase 1
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    P15331Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Fatty-acid amide hydrolase 1
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    P15331Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Fatty-acid amide hydrolase 1
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    P15331Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Fatty-acid amide hydrolase 1
    Monoclonal Antibody for Human Fatty-acid amide hydrolase 1
    Monoclonal Antibody for Human Fatty-acid amide hydrolase 1
    Monoclonal Antibody for Human Fatty-acid amide hydrolase 1
    Monoclonal Antibody for Human Fatty-acid amide hydrolase 1
    Protein for Human Fatty-acid amide hydrolase 1
    Protein for Human Fatty-acid amide hydrolase 1
    Protein for Human Fatty-acid amide hydrolase 1
    Protein for Human Fatty-acid amide hydrolase 1

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    Linearity
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    References
    1. 1.
      "Molecular characterization of human and mouse fatty acid amide hydrolases."
      Giang D.K. , Cravatt B.F.
      Proc. Natl. Acad. Sci. U.S.A.94:2238-2242(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    2. 2.
      "Conserved chromosomal location and genomic structure of human and mouse fatty-acid amide hydrolase genes and evaluation of clasper as a candidate neurological mutation."
      Wan M. , Cravatt B.F. , Ring H.Z. , Zhang X. , Francke U.
      Genomics54:408-414(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      NIEHS SNPs program
      Submitted (2004-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT THR-129
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT THR-129
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    7. 7.
      "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
      Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 456-463
      tissue: Platelet.
    8. 8.
      "A second fatty acid amide hydrolase with variable distribution among placental mammals."
      Wei B.Q. , Mikkelsen T.S. , McKinney M.K. , Lander E.S. , Cravatt B.F.
      J. Biol. Chem.281:36569-36578(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TOPOLOGY;ENZYME REGULATION;TISSUE SPECIFICITY
    9. 9.
      "A missense mutation in human fatty acid amide hydrolase associated with problem drug use."
      Sipe J.C. , Chiang K. , Gerber A.L. , Beutler E. , Cravatt B.F.
      Proc. Natl. Acad. Sci. U.S.A.99:8394-8399(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM;ASSOCIATION OF VARIANT THR-129 WITH SUSCEPTIBILITY TO POLYSUBSTANCE ABUSE;CHARACTERIZATION OF VARIANT THR-129
    10. 10.
      "Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use."
      Chiang K.P. , Gerber A.L. , Sipe J.C. , Cravatt B.F.
      Hum. Mol. Genet.13:2113-2119(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT THR-129
    11. 11.
      "The fatty acid amide hydrolase 385 A/A (P129T) variant: haplotype analysis of an ancient missense mutation and validation of risk for drug addiction."
      Flanagan J.M. , Gerber A.L. , Cadet J.L. , Beutler E. , Sipe J.C.
      Hum. Genet.120:581-588(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION OF VARIANT THR-129 WITH SUSCEPTIBILITY TO POLYSUBSTANCE ABUSE
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-345
    13. 13.
      "Association of a functional FAAH polymorphism with methamphetamine-induced symptoms and dependence in a Malaysian population."
      Sim M.S. , Hatim A. , Reynolds G.P. , Mohamed Z.
      Pharmacogenomics14:505-514(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION OF VARIANT THR-129 WITH SUSCEPTIBILITY TO METHAMPHETAMINE DEPENDENCE
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